بررسی اثر ضد دیابتی عصاره آبی گل انارشیطان (Tecomella undulata (Sm.) Seem) در دیابت نوع یک | ||
| زیست قوم شناسی و حفاظت تنوع زیستی | ||
| دوره 2، شماره 3 - شماره پیاپی 7، مهر 1404، صفحه 26-37 اصل مقاله (1.61 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22091/ethc.2025.12847.1058 | ||
| نویسندگان | ||
| عبداله رمضانی قرا1؛ فرشته عزتی قادی* 2؛ سید حمزه حسینی2 | ||
| 1گروه زیست شناسی، دانشکده علوم پایه، دانشگاه جیرفت، جیرفت، ایران | ||
| 2گروه زیست شناسی، دانشکده علوم پایه، دانشگاه جیرفت، جیرفت، ایران. | ||
| چکیده | ||
| هدف: دیابت یک مشکل متابولیکی است که با کاهش ترشح انسولین مشخص میشود. با توجه به عوارض جانبی مصرف انسولین و داروهای شیمیایی، استفاده از گیاهاندارویی با عوارض کمتر توجه بسیاری از محققین را به خود جلب کرده است. هدف از انجام این پژوهش بررسی اثر ضددیابتی عصاره آبی گل انار شیطان در دیابت نوع یک میباشد. مواد و روشها: موشهای صحرایی نر نژاد ویستار به چهار گروه تقسیم شدند که شامل گروههای کنترل، دیابتی، دیابتی تیمار شده با عصاره گل انارشیطان و موشهای تحت تیمار با عصاره انار شیطان. جهت بررسی اثر ضددیابتی عصاره گیاه انارشیطان فاکتورهای مختلفی چون سطح گلوکز سرمی، انسولین، آنزیمهای کبدی، کلیوی و همچنین میزان کلسترول، LDL، HDL و هیستوپاتولوژی بافتهای مختلف مورد بررسی قرار گرفت. نتایج: نتایج حاصل نشان داد که در گروه دیابتی تحت تیمار با عصاره گیاه میزان انسولین سرمی و میزان چربی افزایش و میزان گلوکز، فاکتورهای کبدی و کلیوی کاهش معنیداری را نشان دادند. نتایج هیستوپاتولوژی بافتهای پانکراس، کلیه و کبد موشهای دیابتی تیمار شده با عصاره انار شیطان نسبت به دیابتی شرایط نرمال را نشان داد. نتیجهگیری: عصاره آبی گل انار شیطان میتواند به عنوان یک گیاه دارویی مؤثر در درمان دیابت نوع 1 مطرح باشد و از آن در درمان بیماری و پیشگیری از عوارض جانبی ناشی از دیابت میتوان استفاده کرد. | ||
| کلیدواژهها | ||
| اثر ضددیابتی؛ انار شیطان؛ دیابت نوع یک؛ هیپرگلیسمی | ||
| عنوان مقاله [English] | ||
| Evaluation of the potential antidiabetic effects of the aqueous extract of Tecomella Undulata (Sm.) Seem. flower in type 1 diabetes | ||
| نویسندگان [English] | ||
| َAbdollah Ramzani Ghara1؛ Fereshteh Ezzati Ghadi2؛ Seyed Hamze Hosseini2 | ||
| 1Department of Biology, Faculty of Science, University of Jiroft, Jiroft, Iran. | ||
| 2Department of Biology, Faculty of Science, University of Jiroft, Jiroft, Iran. | ||
| چکیده [English] | ||
| Objective: This study aimed to evaluate the potential antidiabetic effects of the aqueous extract of Tecomella undulata (Sm.) Seem. flowers in a streptozotocin-induced rat model of type 1 diabetes. Materials and Methods: Male Wistar rats were randomly divided into four groups: (1) normal control, (2) diabetic control, (3) diabetic rats treated with Tecomella undulata (Sm.) Seem. flower extract, and (4) non-diabetic rats treated with Tecomella undulata (Sm.) Seem. flower extract. Type 1 diabetes was induced via intraperitoneal injection of streptozotocin. The therapeutic efficacy of the plant extract was assessed by measuring fasting blood glucose, serum insulin levels, hepatic and renal function biomarkers (ALT, AST, ALP, urea, and creatinine), lipid profile parameters (total cholesterol, LDL, HDL, and triglycerides), and through histopathological examination of pancreatic, hepatic, and renal tissues. Results: Treatment with the aqueous extract produced a statistically significant increase in serum insulin and HDL levels, along with a marked reduction in fasting blood glucose and hepatic and renal dysfunction markers in diabetic rats. Histopathological analysis revealed notable improvements in pancreatic islet architecture, hepatic cellular organization, and renal tubular integrity in extract-treated diabetic rats. Conclusion: The findings indicate that the aqueous extract of Tecomella undulata (Sm.) Seem. flowers exhibits significant antidiabetic activity in type 1 diabetic rats. This extract may represent a promising adjunct or alternative therapeutic option for the management of type 1 diabetes. | ||
| کلیدواژهها [English] | ||
| Antidiabetic activity, Diabets type I, Hyper glycemic, Tecomella undulata | ||
| مراجع | ||
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